The DeNovix DS-11 Series Spectrophotometer / Fluorometer and the Thermo Fisher NanoDrop™ One spectrophotometer are both used to perform fast quantification of nucleic acids and proteins. The DeNovix DS-11 Series provides superior limits of detection, the widest dynamic range, an easy-to-use interface and powerful networking features, which surpass the capabilities of the Thermo Fisher NanoDrop™ spectrophotometer. Here we will here we will outline the difference between the DeNovix DS-11 Series Spectrophotometer / Fluorometer and the Thermo Fisher NanoDrop™ One spectrophotometer.
The DS-11 was first introduced to the market in 2013 and was the first UV-Vis spectrophotometer in the world with a customized operating system, touchscreen control and network connection.
Over the years, DeNovix has expanded the instrument’s features and functionality by collaborating with the life science community. The DS-11 Series also includes a fluorometer mode option with higher sensitivity capabilities integrated into the system. The DS-11 FX+ is patented (US9442009) and offers outstanding limits of detection for fluorescence quantification (0.5 pg/μL dsDNA) and microvolume absorbance (0.75 – 37,500 ng/μL dsDNA).
In just one unit, labs can choose the integrated model that fits both current and future research needs with the combination of fluorescence detection, microvolume UV-Vis and cuvette UV-Vis. All DS-11 Series instruments come with a two-year factory warranty from DeNovix.
Table 1: DeNovix DS-11 Series Spectrophotometer / Fluorometer Comparison to Thermo Fisher NanoDrop™ One spectrophotometer
| DeNovix DS-11 Series | Thermo Fisher NanoDrop™ Onec |
|
|---|---|---|
| Spectrophotometer / Fluorometer | Spectrophotometer | |
| Fluorescence Option | Yes - DS-11 FX and DS-11 FX+ (UV, Blue, Red, Green) | None |
| Dynamic Range (dsDNA) | 0.5 pg/μL* - 37500 ng/μL | 0.2 ng/μL - 27500 ng/μL |
| Protein Performance | Outstanding | Only if sample column is properly formed |
| Microvolume Lower Detection Limit | dsDNA: 0.75 ng/μL, BSA: 0.04 mg/mL | dsDNA: 2.0 ng/μL, BSA: 0.06 mg/mL |
| Cuvette Lower Detection Limit | dsDNA: 0.04 ng/μL, BSA: 0.002 mg/mL | dsDNA: 0.2 ng/μL, BSA: 0.006 mg/mL |
| Max Concentration | dsDNA: 37500 ng/μL, BSA: 1125 mg/mL | dsDNA: 27500 ng/μL, BSA: 820 mg/mL |
| Wavelength Range | 190-840 nm | 190-850 nm |
| Absorbance Range | 0.015 - 750 A | 0.04 - 550 A |
| Wavelength Accuracy (Absorbance) | 0.5 nm | 1 nm |
| Absorbance Accuracy | 1.5% at 0.75 AU at 260nm | 3% at 0.97 AU at 302nm |
| Microvolume Pathlength | 0.5 to 0.02 mm | 1.0 to 0.03 mm |
| Pathlength Verification | SmartPath™ technology with Bridge Testing™ verification | Auto adjusting |
| Pathlength Control | Precision screw driven by high resolution motor | Adjustment screw driven by stepper motor |
| Contamination Alert Software | SmartQC™ contamination alerts | Yes |
| Data Export | Network Drives and Printers, Email, USB, Label Printers | USB, Label Printer, Networks |
| Networking | Wi-Fi and Ethernet | Wi-Fi not available in all areas, Ethernet |
| Color Choices | Arctic White, Brazilian Blue, Tungsten Silver, Fire Red | No |
| Ergonomics | Optimized screen and sample pedestal location | Extended reach required |
See the full comparison of the DeNovix DS-11 Series Spectrophotometer / Fluorometer vs. the Thermo Fisher NanoDrop™ One spectrophotometer. Read the full technical note here.
NanoDrop™ and NanoDrop™ One are registered trademarks of Thermo Fisher Scientific and its subsidiaries and are used for identification and references purposes only. DeNovix, DeNovix products and this website are not endorsed by Thermo Fisher Scientific. DeNovix fluorometer products are provided under an intellectual property license from Life Technologies Corporation. See denovix.com/license.
